If Email Spy Pro is in visible mode you have to click on
Uninstall shortcut within Windows Start menu:
Start > Programs > Email Spy Pro > Uninstall
or find Email Spy Pro uninstall record within Add/Remove Programs menu of Windows Control Panel:
Start > Settings > Control Panel > Add/Remove Programs > Email Spy Pro (uninstall only)
If Email Spy Pro is in the stealth mode you can uninstall program via Control Center menu ONLY. At first you have to press program hotkey to start Email Spy Pro Control Center (default hotkey is Ctrl + Alt + Shift + E).

Then click on Program menu and choose Uninstall to uninstall program.
You will need to reboot computer at the end to finish uninstall process.